Localization of a T-cell epitope of superantigen toxic shock syndrome toxin 1 to residues 125 to 158.

and Zheng - Cai Toxin 1 to Residues 125 to 158 Superantigen Toxic Shock Syndrome Localization of a T - Cell Epitope

Localization of a T-Cell Epitope of Superantigen Toxic Shock

Toxic shock syndrome toxin 1 (TSST-1) is a member of the staphylococcal enterotoxin superantigen family. So far, little is known about T-cell epitopes on superantigens. In this study, we developed an improved method for localizing T-cell epitopes on superantigens that involved synthetic peptides plus costimulation by CD28 or phorbol myristate acetate. Using this method, we localized a T-cell ep...

Identification of class II major histocompatibility complex and T cell receptor binding sites in the superantigen toxic shock syndrome toxin 1

Superantigens, in association with class II major histocompatibility complex (MHC) molecules, activate T cells bearing particular beta chain variable domains of the T cell receptor (TCR). Unlike conventional peptide antigens, superantigens bind as intact proteins to TCR and MHC molecules outside their peptide binding sites. To characterize these interactions at the molecular level, random point...

Sequences in both class II major histocompatibility complex alpha and beta chains contribute to the binding of the superantigen toxic shock syndrome toxin 1

Class II major histocompatibility complex (MHC) molecules present peptides derived from processed antigen to antigen-specific CD4-positive T cells. In addition, class II molecules bind with high affinity another class of antigens, termed superantigens. T cell stimulation by superantigens depends almost exclusively on the V beta segment expressed by the T cell receptor (TCR). Mapping of the supe...

Sequences in Both Class II Major Histocompatibility Complex ol and 3 Chains Contribute to the Binding of the Superantigen Toxic Shock Syndrome Toxin 1 By Ned

Class II major histocompatibility complex (MFIC) molecules present peptides derived from processed antigen to antigen-specific CD4-positive T cells. In addition, class II molecules bind with high affinity another class of antigens, termed superantigens. T cell stimulation by superantigens depends almost exclusively on the V3 segment expressed by the T ceil receptor (TCR). Mapping of the superan...